An Introduction to Human Blood Groups by M.D. Fulton Roberts

By M.D. Fulton Roberts

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A very rare experience, which is less easy to explain is the formation of anti-D by some DM persons. The alleles at the E locus are all rare (apart from E and e) and do not display any points of principle different from those at the other loci. Three have been discovered, termed EM, E w and e*. It is not intended that anything should be said here about certain genetical aspects of these closely-linked loci such as the effect of position on the expression of the genes or the interference by some genes in the expression of others, but there is one point of this kind which may prove of considerable practical importance.

Such a scheme may now be set out in its application to one blood group system as an example. The blood group Duffy is chosen. This group receives its name from the patient on whom investigations led to its discovery, and with his permission. I t was not possible to use D or Du as shorthand symbols for this group because these or similar symbols were bespoken in the R h system ; hence F y was adopted. The differentiation of alleles by small and capital letters was avoided and the symbols F y a and Fy & used instead.

Another antigen has recently been discovered in this system, called P*. The other blood-group system, called Lewis, displays a number of interesting features that are not found in other blood groups. It seems that two antigens can be recognised, called Le a and Left, but about 6 per cent, of persons carry neither of these antigens. ; the incidence of Le a is higher in children because children's 64 P AND a LEWIS 65 cells heterozygous for Le are agglutinated but those from adults are not ; this unusual situation has not yet been explained.

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